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FASTEX Study

Purpose: A pilot non-randomised controlled trial to examine the efficacy and the effects on the immune system of a fasting mimicking diet and a supervised exercise program in patients with breast cancer undergoing neoadjuvant treatment.

Inclusion criteria:

  • Women aged 18 years and older, diagnosed with breast cancer and scheduled for neoadjuvant chemotherapy.

Exclusion criteria:

  • Having a body mass index (BMI) lower than 19 kg/m2;
  • Having impaired gastrointestinal function that may alter the digestion and absorption of nutrients (e.g., uncontrolled nausea, vomiting, diarrhoea);
  • Taking medication that can cause hypoglycemia (e.g., insulin for diabetes);
  • Having malnutrition (unintentional weight loss of >5% in the last 6 months);
  • Having an uncontrolled medical condition (other than cancer);
  • Inability to read or understand English;
  • Being pregnant or breastfeeding;
  • Having undertaken 300 min or more of exercise per week in the previous month prior to inclusion in the study;
  • Having an acute illness or musculoskeletal, cardiovascular, or neurological disorder that could inhibit exercise participation.
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